ABSTRACT

To evaluate the relationship between redcell distrubution width (RDW), platelet distribution width (PDW), mean platelet volume (MPV) parameters and the disease severity in Obstructive sleep apnea syndrome (OSAS) patients; to benefit from the biomarkers to take early measures on disease treatment, follow-up and complications (as thromboembolic events and cardiovascular diseases).

Our study is a retrospective and a cross-sectional study and we planned to asses polysomnography (PSG) records of the patients. Patients who were diagnosed with OSAS by PSG were grouped as 108 mild patients with [Respiratory Disturbance Index (RDI): 5-14.9]; 69 moderate patients (RDI: 15-30); 66 severe patients (RDI>30) and 117 patients were control group (RDI<5). The age range was between 18 and 78. Inclusion criterions were routine blood count, RDW, MPV and PDW.

Three hundred and sixty patients were enrolled in the study. 74.2% of them were male; mean age was 46.5. The average patient O2 saturation was 93.2. When moderate OSAS group was compared with the control group, hematocrit (Htc) (p=0.004) and hemoglobin (Hb) (p=0.002) were found to be significantly increased. When severe OSAS group was compared with the control group, MPV (p=0.017) was decreased significantly, Htc (p=0.006) and Hb (p=0.02) were found to be significantly increased.

In our study, when the other groups and the control group were compared, we observed significantly increased Hb and Htc values in moderate and severe OSAS groups, however some other studies gives an increase in MPV we observed a decrease in severe group. Having few number of patients in moderate and severe OSAS groups may have led to such results. Therefore, more extensive and prospective studies are needed.

Keywords: Redcell distrubution width, mean platelet volume, platelet distribution width, Obstructive sleep apnea syndrome