Öz
Obstrüktif uyku apne (OSA) sendromu, tekrarlayan üst solunum yolu tıkanıklıkları ve buna bağlı aralıklı hipoksi ataklarıyla karakterize, giderek yaygınlaşan bir uyku bozukluğudur. OSA, kardiyovasküler, metabolik ve nörolojik morbidite ile ilişkilidir. Son yıllarda, aralıklı hipoksinin neden olduğu oksidatif stres ve enflamasyonun OSA patogenezinde merkezi bir rol oynadığına dair güçlü kanıtlar ortaya çıkmıştır. Bu derleme, OSA ile oksidatif stres arasındaki mekanik bağlantıları, biyobelirteçleri, klinik sonuçları ve tedavi yaklaşımlarını özetlemeyi amaçlamaktadır. Gelecekteki araştırma alanları da insan ve hayvan çalışmalarından elde edilen kanıtlar ışığında tartışılacaktır.
Anahtar Kelimeler:
Obstrüktif uyku apnesi, oksidatif stres, reaktif oksijen türleri
Kaynaklar
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