Öz
Noktürnal hipoksemi genellikle obstrüktif uyku apne sendromu (OSAS) ile ilişkilendirilir; ancak altta yatan kardiyopulmoner ya da tromboembolik hastalıkların da göstergesi olabilir. Aşırı gündüz uykululuğu ve horlama yakınmasıyla başvuran 42 yaşında kadın hastada polisomnografide hafif OSAS saptandı. Normal vücut kitle indeksi ve belirgin solunumsal olayları olmamasına rağmen,noktürnal desaturasyon (ortalama SpO2: %88) izlendi. Ventilasyon–perfüzyon sintigrafisinde pulmoner emboli ile uyumlu subsegmenter perfüzyon defektleri, ekokardiyografide hafif pulmoner hipertansiyon mevcuttu. Genetik analizde homozigot MTHFR C677T ve PAI-1 (4G/4G) mutasyonları tespit edildi. Antikoagülan tedavi ve vitamin desteği sonrası görüntüleme bulguları normale döndü. Noktürnal hipoksemi, özellikle kalıtsal trombofili varlığında, trombotik aktivite ile ilişkili olabilir.
Anahtar Kelimeler:
Nokturinal hipoksi, OSAS, herediter trombofili, kronik tromboembolik pulmoner hipertansiyon
Kaynaklar
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