Öz
Amaç
Uyku bozuklukları, multipl skleroz (MS) hastalarında sık görülen bir semptomdur. Pittsburgh Uyku Kalitesi Endeksi (PSQI), uyku kalitesini değerlendirmek için güvenilir ve pratik bir araçtır. Bu çalışma, MS hastalarında uyku kalitesi ile klinik ve radyolojik özellikler arasındaki ilişkileri incelemiştir.
Gereç ve Yöntem
Bu retrospektif çalışmada, sıkı klinik, radyolojik ve psikiyatrik dışlama kriterleri doğrultusunda 137 MS hastası (PwMS) dahil edildi. Demografik, klinik, bilişsel ve nörogörüntüleme verileri tıbbi kayıtlardan çıkarıldı. Uyku kalitesi PSQI kullanılarak değerlendirildi ve genel puan ≥5 olanlar kötü uyku kalitesine sahip olarak kabul edildi.
Bulgular
Yüz otuz yedi MS hastası arasında, iyi ve kötü uyku kalitesine sahip olanlar arasında demografik, klinik, bilişsel veya radyolojik parametrelerde anlamlı bir fark gözlenmedi. Ancak, kötü uyuyanlarda yürüme hızı anlamlı olarak daha yavaştı (p=0,005). Uykuya dalma süresi ve öznel uyku kalitesi, genel PSQI puanları ile güçlü bir korelasyon gösterdi. Buna karşın, lezyonun yeri, korpus kallosum indeksi ve beyin sapı veya omurilik atrofisi ölçümleri uyku kalitesi ile herhangi bir ilişki göstermedi.
Sonuç
MS hastalarında uyku kalitesi olumsuz etkilenir ve alt ekstremite fiziksel performansı ile ilişkilidir. Hastaların uyku kalitesine ilişkin öz değerlendirmeleri tutarlı görünmektedir. Uykuya dalma süresinin uzaması önemli bir faktördür, ancak uyku süresi ve uyku bozukluğunun etkileri daha az önemlidir.
Anahtar Kelimeler:
Multipl skleroz, uyku kalitesi, Pittsburgh Uyku Kalitesi Endeksi, manyetik rezonans görüntüleme, fiziksel performans, bilişsel işlev, uyku latansı
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