Öz
Amaç
Obstrüktif uyku apne sendromu tanısı (OUAS), polisomnografi için uzun bekleme süreleri nedeniyle gecikebilmektedir. Bu çalışmada serum monosit/yüksek dansiteli lipoprotein kolesterol oranı (MHR) ve matriks metalloproteinaz-2 (MMP-2) düzeylerinin erken tanı koyma ve hastalık şiddetini belirlemedeki değerini değerlendirmeyi amaçladık.
Gereç ve Yöntem
Çalışma kesitsel analitik bir çalışma olarak tasarlanmıştır. Çalışmaya 31 hafif, 38 orta ve 47 ağır OUAS hastası ve 46 OUAS olmayan kontrol olmak üzere 162 yetişkin katılımcı dahil edildi. Klinik ve demografik veriler ile MHR ve MMP-2 düzeyleri kaydedildi ve karşılaştırıldı.
Bulgular
MHR >8,78, OUAS ve OUAS olmayan olguları %73,3 duyarlılık ve %60,9 özgüllük ile ayırt etmektedir (p=0,004). Serum MMP-2 düzeyinin ≤4,01 olması OUAS ve OUAS olmayan olguları %75 duyarlılık ve %50 özgüllük ile ayırt etmektedir (p=0,012). Serum MHR ile %38 duyarlılık ve %92 özgüllük (p=0,025) arasında anlamlı bir pozitif korelasyon, serum MMP-2 ile OSAS şiddeti arasında ise anlamsız bir negatif korelasyon (p=0,291) tespit edilmiştir. Medyan MMP-2 seviyeleri OSAS alt grupları ve kontroller arasında benzer olsa da, MHR OSAS alt gruplarında anlamlı derecede yüksektir. Risk faktörlerinin çok değişkenli bir model kullanılarak yeniden analizi, daha yüksek HDL ve MMP-2 düzeylerinin OSAS gelişme olasılığının azalmasıyla ilişkili olduğunu ortaya koymuştur.
Sonuç
MHR ve MMP-2 değerlerinin OSAS hastalarının belirlenmesinde hızlı ve düşük maliyetli yöntemler olarak yararlı olabileceği sonucuna vardık. Ayrıca, MHR hastalığın şiddetini öngörmede yardımcı olabilir. Bu testlerin değerlendirilmesi, OUAS olduğundan şüphelenilen bir hastada PSG testinin planlanmasına yardımcı olabilir.
Anahtar Kelimeler: Kolesterol, matriks metaloproteinaz-2, monositler, obstrüktif uyku apne sendromu
Kaynakça
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