Öz
Amaç
İltihabi bağırsak hastalıkları (İBH), özellikle ülseratif kolit (ÜK) ve Crohn hastalığı (CH) ekstra-intestinal belirtiler olarak uyku bozuklukları ile ilişkilendirilmiştir. Ortadoğulu bir İBH hastası grubunda uyku kalitesini değerlendirmeyi ve hastalık özellikleri, uyku bozuklukları ve ilişkili komorbiditeler arasındaki bağlantıları değerlendirmeyi amaçladık.
Gereç ve Yöntem
Bu prospektif çalışmaya 2019-2021 yılları arasında hastanemizin kliniğine ayaktan başvuran İBH olguları dahil edilmiştir. Hastalar, çevrimiçi veya telefon anketleri aracılığıyla doğrulanmış insomnia şiddet indeksi, Epworth uykululuk ölçeği, Pittsburgh uyku kalitesi indeksi, obstrüktif uyku apnesi (OSA) için Berlin anketi ve huzursuz bacak sendromu (RLS) anketinin tercümelerini doldurdular. İkili değişkenler için ki-kare testi ve sürekli değişkenler için Student t-testi kullanıldı. Normale uymayan dağılıma sahip veriler için Mann-Whitney U testi kullanıldı.
Bulgular
Seksen iki İBH hastasının (13 CH ve 69 ÜK) uyku kalitesi değerlendirildi. Düşük uyku kalitesi 52 olguda (%63,4) gözlendi. Pankolitisli ÜK hastalarında kısmi koliti olan hastalara göre uyku bozukluğu görülme olasılığı önemli ölçüde daha yüksekti (p=0,015). Yüksek C-reaktif protein (CRP) düzeyleri gösteren hastalarda OSA ve RLS sıklığı anlamlı olarak daha yüksekti (p=0,038 ve p=0,040, sırasıyla).
Sonuç
İBH hastalarının yarısından fazlasında uyku bozukluğu tespit edildi. Bu hastalarda uyku bozuklukları (özellikle pankolitisli ÜK hastalarında) ve OSA ve RLS gibi ilişkili komorbiditelerin (özellikle yüksek CRP düzeylerine sahip hastalarda) taranmasını öneriyoruz, böylece bu hastalardaki uyku kalitesini artırabiliriz.
Anahtar Kelimeler: Uyku, iltihabi bağırsak hastalıkları, ülseratif kolit, Crohn hastalığı
Kaynakça
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